Loading
CSF2RB (Cytokine receptor common subunit beta) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Sarcomas, Leukaemia, Myeloproliferative neoplasms and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signalling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. Location: Membrane (UniProt). Locus 22q12.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CSF2RB" OR ABSTRACT:"CSF2RB" OR TITLE:"colony stimulating factor 2 receptor subunit beta" OR ABSTRACT:"colony stimulating factor 2 receptor subunit beta" OR TITLE:"Cytokine receptor common subunit beta" OR ABSTRACT:"Cytokine receptor common subunit beta" OR TITLE:"IL5RB" OR ABSTRACT:"IL5RB" OR TITLE:"CD131" OR ABSTRACT:"CD131" OR TITLE:"betaGMR" OR ABSTRACT:"betaGMR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSF2RB, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/csf2rb.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/csf2rb.json. Licence CC BY-NC 4.0.