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CHD4 (ATP-dependent chromatin remodeler CHD4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer, Colorectal cancer, Renal cell carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localises to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 12p13.31 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"CHD4" OR ABSTRACT:"CHD4" OR TITLE:"chromodomain helicase DNA binding protein 4" OR ABSTRACT:"chromodomain helicase DNA binding protein 4" OR TITLE:"ATP-dependent chromatin remodeler CHD4" OR ABSTRACT:"ATP-dependent chromatin remodeler CHD4" OR TITLE:"Mi-2b" OR ABSTRACT:"Mi-2b" OR TITLE:"Mi2-BETA" OR ABSTRACT:"Mi2-BETA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CHD4, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/chd4.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/chd4.json. Licence CC BY-NC 4.0.