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CDK12 (Cyclin-dependent kinase 12) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to oestrogen inhibitors. Location: Nucleus; Nucleus speckle (UniProt). Locus 17q12 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 1-6% | Biallelic inactivating mutation | cBioPortal mutation: 9 of 494, 1.8%, in prad_tcga_pan_can_atlas_2018; 1 of 477, 0.2%, in prad_cpcg_2017; 33 of 1,013, 3.3%, in prad_p1000; 24 of 424, 5.7%, in prad_mcspc_mskcc_2020; 130 of 2,260, 5.8%, in prostate_msk_2024; 88 of 1,465, 6.0%, in prad_cdk12_mskcc_2020; 26 of 444, 5.9%, in prad_su2c_2019; 6 of 114, 5.3%, in nepc_wcm_2016. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CDK12" OR ABSTRACT:"CDK12" OR TITLE:"cyclin dependent kinase 12" OR ABSTRACT:"cyclin dependent kinase 12" OR TITLE:"Cyclin-dependent kinase 12" OR ABSTRACT:"Cyclin-dependent kinase 12" OR TITLE:"CRK7" OR ABSTRACT:"CRK7" OR TITLE:"KIAA0904" OR ABSTRACT:"KIAA0904" OR TITLE:"CRKRS" OR ABSTRACT:"CRKRS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK12, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cdk12.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cdk12.json. Licence CC BY-NC 4.0.