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CD70 is a protein normally only on activated immune cells, but permanently switched on in kidney cancer and some leukaemias. This dossier gathers the 2 products (0 approved), 2 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
CD70 is the TNF-family ligand for CD27.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Renal cell carcinoma | 80-90% | Clear-cell, IHC | Wikipedia | |
| Acute myeloid leukaemia | 30-50% | Blasts and leukaemic stem cells | Wikipedia |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Phase 2 |
|---|---|
| Antibody 1 | |
| Cell therapy 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 2 | Active | A Phase 2 Study of Cusatuzumab Plus Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy | - | ||
A Phase 1/2 Trial of ADI-270 in ccRCC NCT06480565 | 1/2 | Active | A Phase 1/2 Trial of ADI-270 (Engineered γδ Chimeric Receptor [CAR] Vδ1 T Cells Targeting CD70) in Adults With Relapsed or Refractory (R/R) Clear Cell Renal Cell Carcinoma (ccRCC) | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CD70" OR ABSTRACT:"CD70") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD70, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cd70.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cd70.json. Licence CC BY-NC 4.0.