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APH1B (Gamma-secretase subunit APH-1B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilising cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Location: Membrane (UniProt). Locus 15q22.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"APH1B" OR ABSTRACT:"APH1B" OR TITLE:"aph-1B gamma-secretase subunit" OR ABSTRACT:"aph-1B gamma-secretase subunit" OR TITLE:"Gamma-secretase subunit APH-1B" OR ABSTRACT:"Gamma-secretase subunit APH-1B" OR TITLE:"APH-1B" OR ABSTRACT:"APH-1B" OR TITLE:"DKFZp564D0372" OR ABSTRACT:"DKFZp564D0372") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APH1B, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/aph1b.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/aph1b.json. Licence CC BY-NC 4.0.