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APH1A (Gamma-secretase subunit APH-1A) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Location: Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane (UniProt). Locus 1q21.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"APH1A" OR ABSTRACT:"APH1A" OR TITLE:"aph-1A gamma-secretase subunit" OR ABSTRACT:"aph-1A gamma-secretase subunit" OR TITLE:"Gamma-secretase subunit APH-1A" OR ABSTRACT:"Gamma-secretase subunit APH-1A" OR TITLE:"APH-1A" OR ABSTRACT:"APH-1A" OR TITLE:"CGI-78" OR ABSTRACT:"CGI-78") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APH1A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/aph1a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/aph1a.json. Licence CC BY-NC 4.0.