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ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Location: Cytoplasm; Nucleus; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 10p12.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ABI1" OR ABSTRACT:"ABI1" OR TITLE:"abl interactor 1" OR ABSTRACT:"abl interactor 1" OR TITLE:"Abl interactor 1" OR ABSTRACT:"Abl interactor 1" OR TITLE:"E3B1" OR ABSTRACT:"E3B1" OR TITLE:"ABI-1" OR ABSTRACT:"ABI-1" OR TITLE:"SSH3BP1" OR ABSTRACT:"SSH3BP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABI1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/abi1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/abi1.json. Licence CC BY-NC 4.0.