What changed: Wilms tumour (nephroblastoma)

When this page itself was last checked or edited.

Nephrectomy alone with close surveillance (AREN0532).

A milestone in how this cancer is treated.

Vincristine, actinomycin D, doxorubicin (DD-4A) for 24 weeks; flank/abdominal radiotherapy for stage III; whole-lung radiotherapy for lung metastases not in rapid complete response (AREN0533).

Nephrectomy alone was adequate for very low-risk favourable-histology Wilms tumour, and intensified therapy improved outcomes for tumours with 1p and 16q loss of heterozygosity.

Overall 4-year EFS 85.

A milestone in how this cancer is treated.

15-year all-cause mortality among five-year survivors fell from 12.

A milestone in how this cancer is treated.

First Wilms tumour gene; also links to WAGR and Denys-Drash.

Cooperative-group model that raised survival from ~30% to ~90% over five trials.

Wilms tumour, rhabdomyosarcoma, Ewing sarcoma, gestational trophoblastic neoplasia, metastatic testicular cancer, regional perfusion for sarcoma

Acute leukaemia; Hodgkin and non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, Wilms tumour

Combined with surgery and radiation, cure rates begin to climb.

A milestone in how this cancer is treated.