What changed: Small intestine cancer (small bowel adenocarcinoma)

When this page itself was last checked or edited.

Fluoropyrimidine with oxaliplatin (CAPOX or FOLFOX) for six months, extrapolated from colon cancer; BALLAD is the randomised test. (NCCN Category 2A)

A milestone in how this cancer is treated.

Previously treated MSI-high or dMMR endometrial, biliary, colorectal, gastric or small intestine cancer

A milestone in how this cancer is treated.

Small bowel adenocarcinoma is one of the eligible tumours.

First randomised trial in resected small bowel adenocarcinoma (NCT02502370).

Schrock and colleagues (JAMA Oncol 2017) later show SBA is genomically distinct from colorectal and gastric cancer, with frequent dMMR and ERBB2 alterations.

Registry analyses show the distinct site distribution and association with Crohn's, coeliac and FAP.