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Cancers
Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
What changed

Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)

What changed: Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)

Cancer page →

Every dated change on the records linked to Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Overview Types and stages Symptoms and diagnosis Treatment Trials and papers Biology and targets Countries and centres Decisions and support Pipeline and open problems Data

Trial result1Guideline2Milestone7This record1On Edge

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September 2026 · 1

2026-09-10This recordMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Facts on this page last checked
When this page itself was last checked or edited.

2023 · 2

2023Trial resultLIBRETTO-531
LIBRETTO-531 reported
PFS HR 0.
2023MilestoneSelpercatinib
LIBRETTO-531: selpercatinib beats multikinase inhibitors in RET-mutant MTC
Hadoux and colleagues, NEJM.

2020 · 1

2020MilestoneSelpercatinib
Selpercatinib and pralsetinib approved for RET-mutant MTC
A milestone in how this cancer is treated.

2015 · 2

2015GuidelineMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Guideline American Thyroid Association medullary thyroid carcinoma guideline 2015: MEN2 carriers (RET-positive)
Prophylactic total thyroidectomy timed by ATA risk level (highest risk within the first year, high risk before age 5, moderate risk guided by calcitonin); annual screening for pheochromocytoma and hyperparathyroidism.
2015MilestoneThyroid cancer
ATA guideline: codon-based timing of prophylactic thyroidectomy
A milestone in how this cancer is treated.

2012 · 1

2012GuidelineMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Guideline MEN1 clinical practice guidelines (Thakker, JCEM 2012): MEN1 carriers
Surveillance from childhood; subtotal or total parathyroidectomy with autotransplantation for hyperparathyroidism; proton pump inhibitors for gastrinoma; resection of functioning or larger PanNETs; sporadic NET pathways (somatostatin analogues, everolimus, sunitinib, PRRT) for advanced disease.

1997 · 1

1997MilestoneMenin
MEN1 gene cloned
Chandrasekharappa and colleagues, Science; menin identified.

1993 · 1

1993MilestoneRET
RET mutations cause MEN2A
Mulligan and colleagues, Nature; Donis-Keller and colleagues.

1961 · 1

1961MilestoneMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Sipple describes the association of pheochromocytoma and thyroid carcinoma (MEN2)
A milestone in how this cancer is treated.

1954 · 1

1954MilestoneMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Wermer describes familial adenomatosis of endocrine glands (MEN1)
A milestone in how this cancer is treated.