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Cancers
Extrahepatic cholangiocarcinoma (perihilar and distal)
What changed

Extrahepatic cholangiocarcinoma (perihilar and distal)

What changed: Extrahepatic cholangiocarcinoma (perihilar and distal)

Cancer page →

Every dated change on the records linked to Extrahepatic cholangiocarcinoma (perihilar and distal), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Overview Types and stages Symptoms and diagnosis Treatment Trials and papers Biology and targets Countries and centres Decisions and support Pipeline and open problems Data

Trial result9Milestone7This record1On Edge

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September 2026 · 1

2026-09-17This recordExtrahepatic cholangiocarcinoma (perihilar and distal)
Facts on this page last checked
When this page itself was last checked or edited.

2025 · 1

2025Trial resultSWOG S1815
SWOG S1815 reported
OS 14.

2024 · 1

2024MilestoneZanidatamab
Zanidatamab receives accelerated approval for HER2-positive biliary tract cancer
A milestone in how this cancer is treated.

2023 · 3

2023Trial resultASCOT (JCOG1202)
ASCOT (JCOG1202) reported
3-year overall survival 77.
2023Trial resultHERIZON-BTC-01
HERIZON-BTC-01 reported
Confirmed ORR by independent central review 41.
2023Trial resultKEYNOTE-966
KEYNOTE-966 reported
OS 12.

2022 · 2

2022Trial resultTOPAZ-1
TOPAZ-1 reported
OS HR 0.
2022MilestoneTOPAZ-1
TOPAZ-1: durvalumab added to gemcitabine-cisplatin
A milestone in how this cancer is treated.

2021 · 1

2021MilestoneFOLFOX (5-FU, leucovorin, oxaliplatin)
ABC-06: FOLFOX as second line
A milestone in how this cancer is treated.

2019 · 2

2019Trial resultABC-06
ABC-06 reported
Modified FOLFOX plus active symptom control modestly improved overall survival over active symptom control alone.
2019MilestoneBILCAP
BILCAP: adjuvant capecitabine after resection
A milestone in how this cancer is treated.

2017 · 1

2017Trial resultBILCAP
BILCAP reported
OS 51.

2015 · 1

2015Trial resultSWOG S0809
SWOG S0809 reported
2-year OS 65% (R0 67%, R1 60%); median OS 35 months; grade 3 and 4 toxicity 52% and 11%.

2010 · 2

2010Trial resultABC-02
ABC-02 reported
OS 11.
2010MilestoneABC-02
ABC-02: gemcitabine plus cisplatin standard for advanced biliary cancer
A milestone in how this cancer is treated.

1975 · 1

1975MilestoneExtrahepatic cholangiocarcinoma (perihilar and distal)
Bismuth and Corlette classify perihilar tumours by ductal extension
A milestone in how this cancer is treated.

1965 · 1

1965MilestoneExtrahepatic cholangiocarcinoma (perihilar and distal)
Klatskin describes adenocarcinoma at the hepatic duct bifurcation
A milestone in how this cancer is treated.