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Craniopharyngioma
What changed

Craniopharyngioma

What changed: Craniopharyngioma

Cancer page →

Every dated change on the records linked to Craniopharyngioma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Overview Types and stages Symptoms and diagnosis Treatment Trials and papers Biology and targets Countries and centres Decisions and support Pipeline and open problems Data

Approval2Trial result1Guideline2Milestone6This record1On Edge

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September 2026 · 1

2026-09-10This recordCraniopharyngioma
Facts on this page last checked
When this page itself was last checked or edited.

2026 · 2

2026ApprovalSetmelanotide
Setmelanotide approved in US
Acquired hypothalamic obesity in adults and children aged 4 years and older
2026Trial resultTRANSCEND
TRANSCEND reported
Least-squares mean change in body-mass index at 52 weeks minus 16.

2024 · 2

2024GuidelineCraniopharyngioma
Guideline Alliance A071601 (Lancet Oncology 2024): Papillary craniopharyngioma, BRAF V600E
BRAF plus MEK inhibition (vemurafenib-cobimetinib per Alliance A071601, or dabrafenib-trametinib) before or instead of extensive surgery; radiotherapy after response.
2024MilestoneVemurafenib
Alliance A071601 published
Vemurafenib plus cobimetinib produces responses in nearly all BRAF V600E papillary craniopharyngiomas (Lancet Oncology).

2020 · 1

2020ApprovalSetmelanotide
Setmelanotide approved in US
Chronic weight management in obesity due to POMC, PCSK1 or LEPR deficiency

2016 · 1

2016MilestoneCraniopharyngioma
Hypothalamus-sparing surgery recommended
KRANIOPHARYNGEOM 2007 shows radical resection with hypothalamic injury worsens quality of life without improving control.

2015 · 1

2015MilestoneDabrafenib + trametinib
First dramatic response to BRAF/MEK inhibition in papillary craniopharyngioma
Case report (JNCI) leads to the Alliance A071601 trial.

2014 · 1

2014MilestoneBRAF
BRAF V600E found in papillary craniopharyngioma
Brastianos and colleagues (Nature Genetics) show near-universal BRAF V600E in PCP and CTNNB1 in ACP.

2007 · 1

2007GuidelineCraniopharyngioma
Guideline KRANIOPHARYNGEOM 2007; NCI PDQ: Hypothalamic involvement
Hypothalamus-sparing subtotal resection or cyst drainage followed by conformal or proton radiotherapy; intracystic therapy for predominantly cystic tumours.

2005 · 1

2005MilestoneCraniopharyngioma
Nuclear beta-catenin and CTNNB1 mutations define adamantinomatous tumours
A milestone in how this cancer is treated.

1932 · 1

1932MilestoneCraniopharyngioma
Cushing names craniopharyngioma
A milestone in how this cancer is treated.