What changed: Chordoma

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Phase 2 of GI-6301 yeast-brachyury vaccine with radiation (NCT02383498).

WHO classification of soft tissue and bone tumours, fifth edition.

Regorafenib improved eight-week progression-free survival over placebo in relapsed osteosarcoma, with signals in the Ewing sarcoma and chondrosarcoma cohorts.

En bloc resection with negative margins by a spine or skull-base team, followed by high-dose proton or carbon-ion radiotherapy; intralesional surgery is associated with early recurrence. (NCCN Category 2A)

First international recommendations on surgery, radiotherapy and systemic therapy (Lancet Oncol).

Stacchiotti and colleagues: disease stabilisation in most patients, few objective responses.

Yang and colleagues (Nat Genet).

Vujovic and colleagues show near-universal nuclear brachyury expression.

First description of the notochord-derived tumour.