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Every dated change on the records linked to Advanced and metastatic adrenocortical carcinoma (ENSAT stage IV or unresectable), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.
Gemcitabine with capecitabine; cabozantinib; pembrolizumab, especially for mismatch-repair-deficient tumours; streptozocin-mitotane; clinical trials.
Mitotane from diagnosis with glucocorticoid replacement; adrenal enzyme inhibitors (metyrapone, osilodrostat, ketoconazole) for cortisol excess; thromboprophylaxis and infection vigilance.
Etoposide, doxorubicin and cisplatin with mitotane (EDP-M, FIRM-ACT).
Mitotane alone, with resection, thermal ablation or stereotactic radiotherapy of limited metastases.
Relacorilant with checkpoint inhibition for cortisol-secreting tumours; cabozantinib with immunotherapy; radiolabelled CYP11B tracers.