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4 slides generated from the cancer page, with a quiz from the open benchmark and speaker notes that cite the sources. Arrow keys move between slides; Print gives one slide per page.
VIPoma is a very rare pancreatic neuroendocrine tumour that secretes vasoactive intestinal peptide, causing litres of watery diarrhoea a day with dangerous loss of potassium. Most have spread to the liver by diagnosis. Fluid replacement and somatostatin analogues control the diarrhoea, surgery cures the few caught early, and the usual neuroendocrine tumour treatments are used for spread.
VIPoma is a functioning pancreatic neuroendocrine tumour secreting vasoactive intestinal peptide, producing the Verner-Morrison syndrome of watery diarrhoea, hypokalaemia and achlorhydria (Pancreatology 2021). In the French GTE series of 22 patients with strictly confirmed diagnoses, tumours were mostly metastatic (77 percent) and grade 2 (83 percent), median follow-up was 78.2 months, surgical excision of non-metastatic tumours controlled the secretory syndrome, and the antisecretory (over 50 percent fall in bowel movements) and antitumour efficacy of each treatment received was recorded (Pancreatology 2021).
How it differs from its parent: the emergency is metabolic rather than oncological; secretory diarrhoea persists during fasting and can cause renal failure and arrhythmia, so rehydration and octreotide come before any tumour-directed treatment.
| Setting | Approach | Guideline |
|---|---|---|
| All cases | Rehydration and potassium; somatostatin analogues for the syndrome; resection when localised; the parent page's pathways for metastatic disease. | not mapped |