Loading
Newly diagnosed glioblastoma, age 70 or under, performance status 0-2 (hypofractionated variants for older patients)
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Temozolomide (concurrent) Oral alkylating chemotherapy | 75 mg/m² daily for 42 days with radiotherapy 60 Gy in 30 fractions | Oral | D1-28 | weeks 1-6 |
Temozolomide (adjuvant) Oral alkylating chemotherapy | 150 mg/m² cycle 1, then 200 mg/m² | Oral | D1-5 | cycles 1-6, starting 4 weeks after radiotherapy |
Radiotherapy | 2 Gy per fraction, 5 days a week | Radiotherapy | D1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 22, 23, 24, 25, 26 |
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.