Cancers & treatments·Regimen libraryCurative

R-CHOP

Checked 2026-09-09

Diffuse large B-cell lymphoma, first line (6 cycles; 3-4 with radiotherapy for limited stage)

Also called R-CHOP-21.

One cycle

every 21 days × 6 · about 18 weeks in total

21-day cycle × 6 (about 18 weeks)IntravenousOral Daily oral course

Components

Drug	Dose	Route	Days
Rituximab Monoclonal antibody (anti-CD20, chimeric)	375 mg/m²	IV	D1
Cyclophosphamide Alkylating agent (oxazaphosphorine prodrug)	750 mg/m²	IV	D1
Doxorubicin Cytotoxic chemotherapy (anthracycline)	50 mg/m²	IV	D1
Vincristine Vinca alkaloid (microtubule inhibitor)	1.4 mg/m² (maximum 2 mg)	IV	D1
Prednisone	100 mg once daily	Oral	D1-5

Cycles

21-day cycle

Emetogenicity

Moderate (30-90%)

G-CSF

Consider (10-20% FN risk)

Notes

G-CSF is recommended for patients over 65 or with comorbidity (FN risk 10-20%).
Hepatitis B serology before rituximab; check LVEF before doxorubicin.

Used in

Diffuse large B-cell lymphoma Follicular lymphoma Mantle cell lymphoma

Trials

POLARIX

Products

RituximabCyclophosphamideDoxorubicinVincristine

Source

Coiffier (GELA LNH-98.5), NEJM 2002

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.