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Localised anal squamous cell carcinoma, definitive treatment
Also called Nigro regimen.
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Mitomycin Alkylating antibiotic (bioreductive) | 10 mg/m² (maximum 20 mg) | IV | D1, 29 | |
Fluorouracil infusion Fluoropyrimidine antimetabolite | 1,000 mg/m² per day | IV | D1, 2, 3, 4, 29, 30, 31, 32 (96 h infusion) | |
Radiotherapy | 50.4-54 Gy in 28-30 fractions | Radiotherapy | D1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 22, 23, 24, 25, 26, 29, 30, 31, 32, 33, 36, 37, 38, 39, 40 |
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.