Cancers & treatments·Regimen libraryMaintenance

Lenalidomide maintenance

Checked 2026-09-09

After autologous transplant

One cycle

every 28 days

28-day cycle, until progression (or 2 years in some protocols)Oral Daily oral course

Components

Drug	Dose	Route	Days	Note
Lenalidomide Immunomodulatory drug (cereblon E3 ligase modulator)	10 mg once daily (15 mg after 3 months if tolerated)	Oral	D1-21

Cycles

until progression (or 2 years in some protocols)

28-day cycle

Emetogenicity

Minimal (<10%)

G-CSF

Not routine

Notes

Second primary malignancies are increased; the OS benefit outweighs them.

Used in

Multiple myeloma

Products

Lenalidomide

Source

McCarthy meta-analysis, JCO 2017

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.