Cancers & treatments·Regimen libraryCurative

JEB (carboplatin, etoposide, bleomycin)

Checked 2026-09-09

Malignant extracranial germ cell tumours in children (UK Children's Cancer Study Group), a carboplatin-based alternative to cisplatin regimens

Also called JEB.

One cycle

every 21 days × 4-6 · about 12 weeks in total

21-day cycle × 4-6 (two beyond marker normalisation) (about 12 weeks)Intravenous

Components

Drug	Dose	Route	Days
Carboplatin Cytotoxic chemotherapy (platinum)	600 mg/m² (or dosed to GFR)	IV	D2
Etoposide Topoisomerase II inhibitor (podophyllotoxin derivative)	120 mg/m²	IV	D1-3
Bleomycin Glycopeptide antibiotic (DNA-cleaving)	15 mg/m²	IV	D3

Cycles

4-6 (two beyond marker normalisation)

21-day cycle

Emetogenicity

High (>90%)

G-CSF

Not routine

Notes

Carboplatin replaced cisplatin to spare children's hearing and kidneys, with cure rates comparable to cisplatin-based regimens in this study.
Bleomycin is given once per cycle, less often than in adult BEP.

Used in

Germ cell tumours of childhood and adolescence (extracranial and CNS)

Products

CarboplatinEtoposideBleomycin

Source

Mann (UKCCSG GC2), JCO 2000: carboplatin, etoposide and bleomycin for children's germ cell tumours

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.

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