Invasive breast carcinoma of no special type (invasive ductal carcinoma)
Prepared with OnCo (onco.cc/prep/invasive-breast-carcinoma-no-special-type/). Orientation, not medical advice; your team knows your case.
My details
What I know, what is unclear, changes to discuss
Saved in this browserMy questions
8 on the sheet- 1.What is my exact diagnosis, stage, and grade, and which tests established them?
- 2.Which biomarkers have been tested on my tumour (for example Oestrogen receptor, progesterone receptor and HER2, Nottingham grade, Ki-67 and genomic assaysin early HR-positive disease), and what were the results?
- 3.Which subtype is my cancer, and does that change the recommended treatment?
- 4.Is germline (inherited) genetic testing recommended for me or my family?
- 5.For my situation (all stages), which of the standard options do you recommend and why?
- 6.Am I a candidate for Oncotype DX, and what side effects should I expect?
- 7.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
- 8.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
The words I may hear
- Tumour size on a breast report, and why it differs from the scan: The size on the pathology report is the largest continuous lump of invasive cancer measured under the microscope, which is not the same as the size on the mammogram or the MRI.
- Grade, stage and receptor status: three different things on one breast report: A breast report gives three answers to three different questions: the grade says how the cells behave, the stage says how far the cancer has gone, and the receptors say which drugs it will respond to.
- Nottingham Prognostic Index (NPI), and PREDICT: One number that puts a breast cancer's size, its node status and its grade together, because the stage on its own leaves grade out.
- Ducts, lobules and the terminal duct lobular unit: The breast is a tree: fifteen to twenty branching duct systems, each ending in a cluster of milk-making sacs called a lobule.
- Nottingham grade (breast cancer grade 1, 2 and 3): The grade on a breast report is a sum of three scores: how much of the tumour still forms tubes, how ugly its nuclei are, and how many cells are caught dividing.
- The WHO classification of breast tumours, and what the 6th edition changed: The book that decides what a breast tumour is called.
Tests and results to bring
Biomarker results to ask for: Oestrogen receptor, progesterone receptor and HER2, Nottingham grade, Ki-67 and genomic assays (Oncotype DX and others) in early HR-positive disease.
Scans and tests linked to this cancer: Companion diagnostics, RNA sequencing & expression profiling, Gene-expression prognostic assays.
Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.
The treatments I may be offered
- All stages: Treated as the parent's receptor pages describe. (Breast cancer (all types), HR-positive / HER2-negative breast cancer, HER2-positive breast cancer, Triple-negative breast cancer (TNBC), Oncotype DX)
From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.