{"slug":"trial-design","tag":"trial-design","variants":["trial-design"],"description":"No description yet","count":2,"kinds":{"person":1,"trial":1},"related":[{"slug":"biostatistics","tag":"biostatistics","shared":1},{"slug":"exercise","tag":"exercise","shared":1},{"slug":"open-problem","tag":"open-problem","shared":1},{"slug":"platform-trials","tag":"platform-trials","shared":1},{"slug":"rejuvenation","tag":"rejuvenation","shared":1},{"slug":"survivorship","tag":"survivorship","shared":1}],"records":[{"id":"mahesh-parmar","kind":"person","name":"Mahesh K. B. Parmar","route":"/people/mahesh-parmar/","tldr":"Statistician who invented the multi-arm multi-stage design behind STAMPEDE, letting one trial test many treatments at once."},{"id":"rejuv-trial-amico","kind":"trial","name":"AMICO: aerobic or resistance exercise to improve outcome in metastatic colorectal cancer","route":"/trials/rejuv-trial-amico/","status":"recruiting","tldr":"CHALLENGE showed exercise improves survival after curative treatment for colon cancer. AMICO asks the next question, in advanced disease, with chemotherapy dose modification and progression-free survival as its primary endpoints, and uses an adaptive design to drop an ineffective exercise prescription early."}]}