{"slug":"genomics","tag":"genomics","variants":["genomics"],"description":"People and fronts concerned with cancer genomics.","count":25,"kinds":{"institution":1,"person":23,"section":1},"related":[{"slug":"clinician-scientist","tag":"clinician-scientist","shared":5},{"slug":"leadership","tag":"leadership","shared":5},{"slug":"uk","tag":"uk","shared":4},{"slug":"breast","tag":"breast","shared":3},{"slug":"classification","tag":"classification","shared":2},{"slug":"computational","tag":"computational","shared":2},{"slug":"liquid-biopsy","tag":"liquid-biopsy","shared":2},{"slug":"mutational-signatures","tag":"mutational-signatures","shared":2},{"slug":"paediatric","tag":"paediatric","shared":2},{"slug":"pancreatic","tag":"pancreatic","shared":2},{"slug":"bioinformatics","tag":"bioinformatics","shared":1},{"slug":"breast-cancer","tag":"breast cancer","shared":1}],"records":[{"id":"wolfson-wohl-cancer-research-centre","kind":"institution","name":"Wolfson Wohl Cancer Research Centre, University of Glasgow","route":"/institutions/wolfson-wohl-cancer-research-centre/","tldr":"The University of Glasgow's cancer research centre on the Garscube estate, home to Andrew Biankin's pancreatic cancer genomics group and the Precision-Panc programme that ran the PRIMUS trials through NHS Greater Glasgow and Clyde."},{"id":"andrew-biankin","kind":"person","name":"Andrew Biankin","route":"/people/andrew-biankin/","tldr":"The Glasgow surgeon-scientist who mapped the genomic subtypes of pancreatic cancer and built Precision-Panc, the UK programme that profiled tumours to route patients into the PRIMUS trials."},{"id":"alastair-greystoke","kind":"person","name":"Alastair Greystoke","route":"/people/alastair-greystoke/","tldr":"The Newcastle oncologist who led the NHS England pilot that put a blood test for lung cancer mutations into the diagnostic pathway, and who co-leads the CONCORDE radiotherapy platform."},{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/","tldr":"Tests on tissue and blood that say what kind of cancer it is, what is driving it, and which drugs might work."},{"id":"matthew-hurles","kind":"person","name":"Matthew Hurles","route":"/people/matthew-hurles/","tldr":"Human geneticist who directs the Wellcome Sanger Institute, a world centre for cancer genome research."},{"id":"ewan-birney","kind":"person","name":"Ewan Birney","route":"/people/ewan-birney/","tldr":"Computational biologist who directs EMBL-EBI, home of the open genomic and cancer data resources used worldwide."},{"id":"stephen-scherer","kind":"person","name":"Stephen Scherer","route":"/people/stephen-scherer/","tldr":"Genome scientist who heads research at SickKids and co-discovered genome-wide copy number variation in humans."},{"id":"nikolaus-rajewsky","kind":"person","name":"Nikolaus Rajewsky","route":"/people/nikolaus-rajewsky/","tldr":"Systems biologist at the MDC known for microRNA and circular RNA discoveries and for single-cell and spatial genomics applied to cancer."},{"id":"benjamin-kile","kind":"person","name":"Benjamin Kile","route":"/people/benjamin-kile/","tldr":"Blood cell molecular biologist who has led Sydney's Garvan Institute of Medical Research since 2023, sharpening its focus on genomics, immunology and cancer."},{"id":"silvana-konermann","kind":"person","name":"Silvana Konermann","route":"/people/silvana-konermann/","tldr":"Neuroscientist and co-founder who runs the Arc Institute, an independent research institute in the San Francisco Bay Area built to tackle complex diseases."},{"id":"yardena-samuels","kind":"person","name":"Yardena Samuels","route":"/people/yardena-samuels/","tldr":"She found that PIK3CA is one of the most frequently mutated genes in human cancer, then spent the next twenty years working out which of a melanoma's mutations the immune system can actually see."},{"id":"charles-perou","kind":"person","name":"Charles M. Perou","route":"/people/charles-perou/","tldr":"Defined the molecular subtypes of breast cancer (luminal, HER2-enriched, basal-like) that clinicians now use every day."},{"id":"aleix-prat","kind":"person","name":"Aleix Prat","route":"/people/aleix-prat/","tldr":"Translational oncologist who built genomic tests (HER2DX) to decide which HER2-positive patients can skip chemotherapy."},{"id":"douglas-levine","kind":"person","name":"Douglas A. Levine","route":"/people/douglas-levine/","tldr":"Surgeon-scientist who led the TCGA endometrial cancer study that created today's four molecular subtypes."},{"id":"michael-taylor","kind":"person","name":"Michael D. Taylor","route":"/people/michael-taylor/","tldr":"Neurosurgeon-scientist who defined the four molecular subgroups of medulloblastoma that now guide therapy."},{"id":"john-maris","kind":"person","name":"John M. Maris","route":"/people/john-maris/","tldr":"Neuroblastoma geneticist whose lab found the ALK mutations and immunotherapy targets now in paediatric trials."},{"id":"steven-treon","kind":"person","name":"Steven P. Treon","route":"/people/steven-treon/","tldr":"Discovered the MYD88 mutation that defines Waldenström macroglobulinaemia and led the trial that made ibrutinib its first approved drug."},{"id":"nikhil-munshi","kind":"person","name":"Nikhil C. Munshi","route":"/people/nikhil-munshi/","tldr":"Led KarMMa, which brought idecabtagene vicleucel, the first CAR-T for myeloma, to approval."},{"id":"catherine-wu","kind":"person","name":"Catherine J. Wu","route":"/people/catherine-wu/","tldr":"Led the first personalised neoantigen peptide vaccine trial in melanoma and mapped how CLL evolves under treatment."},{"id":"michael-berger","kind":"person","name":"Michael F. Berger","route":"/people/michael-berger/","tldr":"Built MSK-IMPACT, the tumour sequencing test used on more than 100,000 patients and the first FDA-authorised hospital panel."},{"id":"serena-nik-zainal","kind":"person","name":"Serena Nik-Zainal","route":"/people/serena-nik-zainal/","tldr":"Deciphered the mutational signatures written in cancer genomes and turned them into clinical tests like HRDetect."},{"id":"ludmil-alexandrov","kind":"person","name":"Ludmil B. Alexandrov","route":"/people/ludmil-alexandrov/","tldr":"Created the mathematical framework for extracting mutational signatures from cancer genomes and the COSMIC signature catalogue."},{"id":"carlos-caldas","kind":"person","name":"Carlos Caldas","route":"/people/carlos-caldas/","tldr":"Led METABRIC, which used 2,000 tumours to define ten genomic subtypes of breast cancer and their long-term outcomes."},{"id":"christina-curtis","kind":"person","name":"Christina Curtis","route":"/people/christina-curtis/","tldr":"Showed that colorectal cancers grow as a 'Big Bang' and that metastasis can be seeded years before diagnosis."},{"id":"nitzan-rosenfeld","kind":"person","name":"Nitzan Rosenfeld","route":"/people/nitzan-rosenfeld/","tldr":"Showed that whole-exome sequencing of blood can track how a cancer evolves, and co-founded Inivata."}]}