{"slug":"exercise","tag":"exercise","variants":["exercise"],"description":"No description yet","count":8,"kinds":{"section":2,"person":2,"technology":1,"trial":3},"related":[{"slug":"survivorship","tag":"survivorship","shared":6},{"slug":"rejuvenation","tag":"rejuvenation","shared":5},{"slug":"open-problem","tag":"open-problem","shared":3},{"slug":"rehabilitation","tag":"rehabilitation","shared":2},{"slug":"biological-ageing","tag":"biological-ageing","shared":1},{"slug":"cachexia","tag":"cachexia","shared":1},{"slug":"evidence","tag":"evidence","shared":1},{"slug":"fertility","tag":"fertility","shared":1},{"slug":"hair","tag":"hair","shared":1},{"slug":"late-effects","tag":"late-effects","shared":1},{"slug":"microbiome","tag":"microbiome","shared":1},{"slug":"neuropathy","tag":"neuropathy","shared":1}],"records":[{"id":"nutrition-lifestyle","kind":"section","name":"Diet, Exercise & Lifestyle","route":"/fronts/nutrition-lifestyle/","tldr":"What people eat, drink, weigh and do affects who gets cancer, how treatment goes, and who relapses. Those questions are answerable, and the good studies answer them with the rigour of a drug trial."},{"id":"rejuvenation","kind":"section","name":"Recovery & Rejuvenation","route":"/fronts/rejuvenation/","tldr":"What cancer treatment took, and whether it comes back: hair, hearing, fertility, bone, muscle, nerves, memory, the heart, skin, sexual function and the years afterwards. Recovery begins during treatment rather than after it, and structured exercise has more evidence behind it than everything sold as rejuvenation put together."},{"id":"kerry-courneya","kind":"person","name":"Kerry S. Courneya","route":"/people/kerry-courneya/","tldr":"Exercise scientist behind CHALLENGE, the first trial to show a structured exercise programme improves survival after colon cancer."},{"id":"christopher-booth","kind":"person","name":"Christopher M. Booth","route":"/people/christopher-booth/","tldr":"Oncologist who co-led CHALLENGE and founded Common Sense Oncology to refocus trials on outcomes that matter to patients."},{"id":"rejuv-frontier-what-works","kind":"technology","name":"What actually works after treatment","route":"/technologies/rejuv-frontier-what-works/","status":"established","tldr":"Exercise, sleep, not smoking, treating what is treatable and keeping up surveillance outperform everything currently sold as rejuvenation, by a wide margin and with randomised trials behind them. The measurable ageing that treatment causes is real and is a reason for research, not a reason to buy something."},{"id":"rejuv-trial-proffi","kind":"trial","name":"PROFFi: fisetin and exercise to prevent frailty in breast cancer survivors","route":"/trials/rejuv-trial-proffi/","status":"recruiting","tldr":"The first randomised trial to test a senolytic in people who have had cancer. Four arms crossing fisetin against placebo with tailored supervised exercise against a physical activity handout, and the primary endpoint is how far someone can walk in six minutes."},{"id":"rejuv-trial-ex-cipn","kind":"trial","name":"EX-CIPN: virtual exercise-based rehabilitation for persistent chemotherapy nerve damage","route":"/trials/rejuv-trial-ex-cipn/","status":"recruiting","tldr":"Nothing prevents chemotherapy nerve damage and the only drug with guideline support for the established painful form has a benefit the guideline itself calls limited. This pragmatic trial tests ten weeks of individualised remote exercise against usual care."},{"id":"rejuv-trial-amico","kind":"trial","name":"AMICO: aerobic or resistance exercise to improve outcome in metastatic colorectal cancer","route":"/trials/rejuv-trial-amico/","status":"recruiting","tldr":"CHALLENGE showed exercise improves survival after curative treatment for colon cancer. AMICO asks the next question, in advanced disease, with chemotherapy dose modification and progression-free survival as its primary endpoints, and uses an adaptive design to drop an ineffective exercise prescription early."}]}