{"entity":{"id":"yoda-project","kind":"institution","name":"Yale University Open Data Access (YODA) Project","aka":["YODA Project","YODA"],"tldr":"The Yale programme that acts as independent steward of clinical trial data from Johnson & Johnson and other sponsors, letting outside researchers re-analyse trials including oncology studies.","summary":"Founded in 2011 by Harlan Krumholz and Joseph Ross at Yale, the YODA Project pioneered independent, transparent sharing of participant-level clinical trial data: sponsors (Johnson & Johnson since 2014, with Medtronic and others) hand over data and clinical study reports, and YODA reviews researcher requests against pre-specified criteria, publishing decisions and resulting publications. Its holdings include Janssen oncology trials of abiraterone, daratumumab, ibrutinib and CAR-T, enabling re-analyses of subgroups, toxicity and endpoints. YODA's model influenced the ICMJE data-sharing statement requirements and sits alongside Vivli and Project Data Sphere as the main academic trial data-sharing infrastructure.","asOf":"2026-09-09","links":[{"label":"YODA Project","url":"https://yoda.yale.edu"}],"tags":[],"related":[],"cancers":[],"sections":["ai-computation"],"technologies":[],"targets":[],"drugs":["ciltacabtagene-autoleucel","teclistamab"],"companies":["johnson-johnson"],"institutions":["yale-school-of-medicine","vivli","cdisc"],"pathways":[],"terms":["real-world-evidence"],"trials":[],"people":["harlan-krumholz","joseph-ross"],"bottlenecks":["b-data-silos","b-reproducibility","b-negative-results"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"New Haven, CT","country":"US","lat":41.308,"lng":-72.928,"institutionType":"consortium","website":"https://yoda.yale.edu","programs":["Independent trial data stewardship for Johnson & Johnson and others","Transparent request review and reporting","Data-sharing policy research"]},"route":"/institutions/yoda-project/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"}],"drug":[{"id":"ciltacabtagene-autoleucel","kind":"drug","name":"Ciltacabtagene autoleucel","route":"/drugs/ciltacabtagene-autoleucel/"},{"id":"teclistamab","kind":"drug","name":"Teclistamab","route":"/drugs/teclistamab/"}],"company":[{"id":"johnson-johnson","kind":"company","name":"Johnson & Johnson","route":"/companies/johnson-johnson/"}],"institution":[{"id":"cdisc","kind":"institution","name":"Clinical Data Interchange Standards Consortium","route":"/institutions/cdisc/"},{"id":"vivli","kind":"institution","name":"Vivli","route":"/institutions/vivli/"},{"id":"yale-school-of-medicine","kind":"institution","name":"Yale School of Medicine / Yale Cancer Center","route":"/institutions/yale-school-of-medicine/"}],"term":[{"id":"real-world-evidence","kind":"term","name":"Real-world evidence","route":"/terms/real-world-evidence/"}],"person":[{"id":"harlan-krumholz","kind":"person","name":"Harlan M. Krumholz","route":"/people/harlan-krumholz/"},{"id":"joseph-ross","kind":"person","name":"Joseph S. Ross","route":"/people/joseph-ross/"}],"bottleneck":[{"id":"b-data-silos","kind":"bottleneck","name":"Data silos","route":"/bottlenecks/b-data-silos/"},{"id":"b-negative-results","kind":"bottleneck","name":"Failures are hidden","route":"/bottlenecks/b-negative-results/"},{"id":"b-reproducibility","kind":"bottleneck","name":"Preclinical results do not reproduce","route":"/bottlenecks/b-reproducibility/"}]}}