{"entity":{"id":"xu-jianming","kind":"person","name":"Jianming Xu","aka":["Xu Jian-Ming","徐建明"],"tldr":"Jianming Xu led the Chinese stomach cancer trials of sintilimab, the ADC disitamab vedotin and other domestic drugs, in the country with the most stomach cancer patients.","summary":"Jianming Xu is Professor of Gastrointestinal Oncology at the Fifth Medical Center of the Chinese PLA General Hospital in Beijing. He is best known as principal investigator of ORIENT-16, the randomised trial of sintilimab plus chemotherapy in first-line unresectable gastric and gastro-oesophageal junction cancer reported in JAMA, and of the pivotal gastric cancer study of the HER2 antibody-drug conjugate disitamab vedotin. He has led many Chinese phase 3 trials in gastric, colorectal and oesophageal cancer and is a leading figure in the CSCO gastric cancer guidelines. His trials have brought domestic drugs to the country with the most stomach cancer patients.","asOf":"2026-09-10","links":[{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Xu%20J%5BAuthor%5D%20gastric%20cancer%20307%20Hospital%20PLA"}],"tags":["china"],"related":[],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["sintilimab","disitamab-vedotin"],"companies":[],"institutions":["pla-general-hospital"],"pathways":[],"terms":[],"trials":["orient-16"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Gastrointestinal Oncology; Fifth Medical Center, Chinese PLA General Hospital, Beijing","institutionId":"pla-general-hospital","specialisms":["Gastric cancer","Gastrointestinal oncology","Clinical trials","HER2 ADCs"],"profiles":[{"label":"PubMed author search","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Xu%20J%5BAuthor%5D%20gastric%20cancer%20307%20Hospital%20PLA"}],"papers":[{"title":"Sintilimab plus chemotherapy for unresectable gastric or gastroesophageal junction cancer: the ORIENT-16 randomized clinical trial","journal":"JAMA","year":2023,"doi":"10.1001/jama.2023.19918"}]},"route":"/people/xu-jianming/","neighbours":{"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}],"drug":[{"id":"disitamab-vedotin","kind":"drug","name":"Disitamab vedotin","route":"/drugs/disitamab-vedotin/"},{"id":"sintilimab","kind":"drug","name":"Sintilimab","route":"/drugs/sintilimab/"}],"institution":[{"id":"pla-general-hospital","kind":"institution","name":"Chinese PLA General Hospital","route":"/institutions/pla-general-hospital/"}],"trial":[{"id":"orient-16","kind":"trial","name":"ORIENT-16","route":"/trials/orient-16/"}]}}