{"entity":{"id":"xilis","kind":"company","name":"Xilis","aka":[],"tldr":"Duke spin-out whose MicroOrganoSphere droplets grow a patient's tumour and screen drugs within two weeks.","summary":"MicroOrganoSpheres (MOS) are microfluidic droplet-encapsulated 3D tumour models enabling automated functional drug testing. A 2026 JCO Precision Oncology study in 33 stage III/IV colorectal cancer patients tested feasibility of screening standard-of-care drugs in ≤14 days. Raised $70M Series A; DKFZ collaboration.","asOf":"2026-09-04","links":[{"label":"JCO Precision Oncology 2026","url":"https://ascopubs.org/doi/10.1200/PO-25-00501"}],"tags":[],"related":[],"cancers":["colorectal"],"sections":["diagnostics","drug-discovery"],"technologies":["functional-drug-testing","organoids"],"targets":[],"drugs":[],"companies":[],"institutions":["dkfz"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Durham, NC","country":"US","companyType":"diagnostics","website":"https://xilis.com","investors":[],"funding":[]},"route":"/companies/xilis/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"functional-drug-testing","kind":"technology","name":"Functional (ex vivo) drug testing","route":"/technologies/functional-drug-testing/"},{"id":"organoid-guided-therapy-scale","kind":"technology","name":"Organoid-guided therapy at scale","route":"/technologies/organoid-guided-therapy-scale/"},{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"}],"institution":[{"id":"dkfz","kind":"institution","name":"German Cancer Research Center (DKFZ)","route":"/institutions/dkfz/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"}],"idea":[{"id":"idea-tr2-organoid-coclinical-arms","kind":"idea","name":"Grow each trial patient's tumour as organoids to decide which platform arm opens next","route":"/ideas/idea-tr2-organoid-coclinical-arms/"},{"id":"idea-bio1-organoid-assay-clinical-validation","kind":"idea","name":"Hold organoid drug tests to the same standard as a diagnostic test","route":"/ideas/idea-bio1-organoid-assay-clinical-validation/"},{"id":"idea-bio1-co-clinical-avatar-trials","kind":"idea","name":"Run the mouse or organoid trial at the same time as the human trial","route":"/ideas/idea-bio1-co-clinical-avatar-trials/"},{"id":"idea-bio2-functional-precision-rare","kind":"idea","name":"Test drugs on the patient's own cancer cells when there is no trial to join","route":"/ideas/idea-bio2-functional-precision-rare/"}]}}