{"entity":{"id":"wyndham-wilson","kind":"person","name":"Wyndham H. Wilson","aka":[],"tldr":"Developed dose-adjusted EPOCH-R, the regimen that cures primary mediastinal B-cell lymphoma without radiotherapy.","summary":"Wyndham Wilson developed the infusional dose-adjusted EPOCH regimen and showed that DA-EPOCH-R cures primary mediastinal B-cell lymphoma in more than 90% of patients without radiotherapy, and led the NCI studies of ibrutinib in ABC-subtype DLBCL that linked molecular subtype to treatment response. He co-led the Alliance/CALGB 50303 trial comparing DA-EPOCH-R with R-CHOP and studies of Burkitt lymphoma with reduced-intensity therapy.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Wilson%20WH%5BAuthor%5D%20lymphoma%20EPOCH"}],"tags":["lymphoma","nci","chemotherapy"],"related":[],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":["cd20"],"drugs":[],"companies":[],"institutions":["nci-ccr","nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Senior Investigator and Head, Lymphoma Therapeutics Section, National Cancer Institute Center for Cancer Research","institutionId":"nci-ccr","specialisms":["Aggressive lymphoma","Dose-adjusted EPOCH","Primary mediastinal lymphoma","Molecular subtypes"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Wilson%20WH%5BAuthor%5D%20lymphoma%20EPOCH"}],"papers":[{"title":"Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma","journal":"NEJM","year":2013,"doi":"10.1056/NEJMoa1214561"},{"title":"Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma","journal":"Nature Medicine","year":2015,"doi":"10.1038/nm.3884"}]},"route":"/people/wyndham-wilson/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"primary-mediastinal-b-cell-lymphoma","kind":"cancer","name":"Primary mediastinal (thymic) large B-cell lymphoma","route":"/cancers/primary-mediastinal-b-cell-lymphoma/"}],"target":[{"id":"cd20","kind":"target","name":"CD20","route":"/targets/cd20/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}]}}