{"entity":{"id":"wustl-siteman","kind":"institution","name":"Siteman Cancer Center, Washington University","aka":[],"tldr":"Sequenced the first cancer genome (2008) and leads in neoantigen vaccine science and CIViC.","summary":"Siteman Cancer Center at Washington University in St Louis, NCI-designated as comprehensive, is where the first cancer genome was sequenced in 2008, when the McDonnell Genome Institute performed whole-genome sequencing of an acute myeloid leukaemia, and it leads in neoantigen vaccine science. It is home to the CIViC clinical variant knowledge base built by Malachi Griffith and Obi L. Griffith, the pVACtools neoantigen prediction software and personalised vaccine trials, with Timothy J. Ley, Li Ding, John F. DiPersio and Ramaswamy Govindan among its people. OnCo links it to whole-genome sequencing, to personalised neoantigen mRNA vaccines, to the antigen presentation pathway, and to St Jude Children's Research Hospital. What makes a neoantigen actually immunogenic is the open question its programme exists to answer. Its genomics, CIViC and vaccine programmes are listed below.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://siteman.wustl.edu"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["wes-wgs","neoantigen-mrna-vaccine","proton-therapy","proton-therapy-systems","mr-linac"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["neoantigen"],"trials":[],"people":["timothy-ley","li-ding","malachi-griffith","obi-griffith","john-dipersio","ramaswamy-govindan","robert-schreiber","timothy-eberlein"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"St. Louis, MO","country":"US","lat":38.636,"lng":-90.264,"institutionType":"cancer-center","website":"https://siteman.wustl.edu","nci":"comprehensive","university":"Washington University in St. Louis","programs":["Cancer genomics","CIViC","Neoantigen vaccines"]},"route":"/institutions/wustl-siteman/","neighbours":{"technology":[{"id":"mr-linac","kind":"technology","name":"MR-guided adaptive radiotherapy","route":"/technologies/mr-linac/"},{"id":"neoantigen-mrna-vaccine","kind":"technology","name":"Personalised neoantigen (mRNA) vaccines","route":"/technologies/neoantigen-mrna-vaccine/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"},{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"term":[{"id":"neoantigen","kind":"term","name":"Neoantigen","route":"/terms/neoantigen/"}],"person":[{"id":"john-dipersio","kind":"person","name":"John F. DiPersio","route":"/people/john-dipersio/"},{"id":"li-ding","kind":"person","name":"Li Ding","route":"/people/li-ding/"},{"id":"malachi-griffith","kind":"person","name":"Malachi Griffith","route":"/people/malachi-griffith/"},{"id":"obi-griffith","kind":"person","name":"Obi L. Griffith","route":"/people/obi-griffith/"},{"id":"ramaswamy-govindan","kind":"person","name":"Ramaswamy Govindan","route":"/people/ramaswamy-govindan/"},{"id":"robert-schreiber","kind":"person","name":"Robert D. Schreiber","route":"/people/robert-schreiber/"},{"id":"timothy-eberlein","kind":"person","name":"Timothy J. Eberlein","route":"/people/timothy-eberlein/"},{"id":"timothy-ley","kind":"person","name":"Timothy J. Ley","route":"/people/timothy-ley/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"parker-institute","kind":"institution","name":"Parker Institute for Cancer Immunotherapy","route":"/institutions/parker-institute/"},{"id":"st-jude","kind":"institution","name":"St. Jude Children's Research Hospital","route":"/institutions/st-jude/"}],"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"pathway":[{"id":"antigen-presentation-immunoediting","kind":"pathway","name":"Antigen presentation & immune editing","route":"/pathways/antigen-presentation-immunoediting/"}],"idea":[{"id":"idea-neoantigen-immunogenicity-rules","kind":"idea","name":"What makes a neoantigen actually immunogenic?","route":"/ideas/idea-neoantigen-immunogenicity-rules/"}],"paper":[{"id":"paper-schreiber-cancer-immunoediting-science-2011","kind":"paper","name":"Schreiber, Old and Smyth 2011: cancer immunoediting","route":"/key-papers/paper-schreiber-cancer-immunoediting-science-2011/"}],"company":[{"id":"viewray","kind":"company","name":"ViewRay (MRIdian)","route":"/companies/viewray/"}]}}