{"entity":{"id":"wouter-de-laat","kind":"person","name":"Wouter de Laat","aka":[],"tldr":"Genome biologist who chairs UMC Utrecht's Strategic Program Cancer, the umbrella for more than 800 cancer researchers in Utrecht.","summary":"Wouter de Laat is Chair of the Strategic Program Cancer at UMC Utrecht, which coordinates cancer research across the UMC Utrecht Cancer Center and the Hubrecht Institute. He is a professor of biomedical genomics whose laboratory pioneered chromosome conformation capture (4C) methods to study three-dimensional genome organisation. His work links chromatin structure to gene regulation and disease.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://research.umcutrecht.nl/strategic-programs/cancer/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de+Laat+W%5BAuthor%5D"}],"tags":["leadership","basic science","cancer genomics"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["umc-utrecht"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cell","cancer-cell","nature-communications"],"dependsOn":[],"notes":[],"role":"Chair, Strategic Program Cancer","institutionId":"umc-utrecht","specialisms":["Genome organisation","Chromatin biology","Cancer genomics"],"profiles":[{"label":"Institution profile","url":"https://research.umcutrecht.nl/strategic-programs/cancer/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de+Laat+W%5BAuthor%5D"}],"papers":[{"title":"A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia","journal":"Cell","year":2014,"doi":"10.1016/j.cell.2014.02.019"},{"title":"Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia","journal":"Cancer Cell","year":2011,"doi":"10.1016/j.ccr.2011.02.008"},{"title":"Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA","journal":"Nature Communications","year":2015,"doi":"10.1038/ncomms7520"}],"orcid":"0000-0002-6393-595X"},"route":"/people/wouter-de-laat/","neighbours":{"institution":[{"id":"umc-utrecht","kind":"institution","name":"UMC Utrecht Cancer Center","route":"/institutions/umc-utrecht/"}],"journal":[{"id":"cancer-cell","kind":"journal","name":"Cancer Cell","route":"/journals/cancer-cell/"},{"id":"cell","kind":"journal","name":"Cell","route":"/journals/cell/"},{"id":"nature-communications","kind":"journal","name":"Nature Communications","route":"/journals/nature-communications/"}]}}