{"entity":{"id":"william-tap","kind":"person","name":"William D. Tap","aka":[],"tldr":"Sarcoma oncologist who led ANNOUNCE and the pexidartinib trial that produced the first drug for tenosynovial giant cell tumour.","summary":"William Tap led ANNOUNCE, the phase 3 trial that found olaratumab did not improve survival in soft-tissue sarcoma despite a striking phase 2 result, a widely cited cautionary tale for accelerated approval, and ENLIVEN, which won pexidartinib approval for tenosynovial giant cell tumour. He chairs the Alliance sarcoma committee and leads sarcoma medical oncology at MSKCC.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Tap%20WD%5BAuthor%5D%20sarcoma"}],"tags":["sarcoma","trialist"],"related":[],"cancers":["sarcoma"],"sections":[],"technologies":["kinase-inhibitors"],"targets":[],"drugs":[],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":["announce"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chief, Sarcoma Medical Oncology Service, Memorial Sloan Kettering Cancer Center","institutionId":"mskcc","specialisms":["Soft-tissue sarcoma","Tenosynovial giant cell tumour","Kinase inhibitors","Trial design"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Tap%20WD%5BAuthor%5D%20sarcoma"}],"papers":[{"title":"Effect of doxorubicin plus olaratumab vs doxorubicin plus placebo on survival in patients with advanced soft tissue sarcomas (ANNOUNCE)","journal":"JAMA","year":2020,"doi":"10.1001/jama.2020.1707"},{"title":"Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN)","journal":"Lancet","year":2019,"doi":"10.1016/S0140-6736(19)30764-0"}]},"route":"/people/william-tap/","neighbours":{"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"institution":[{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"trial":[{"id":"announce","kind":"trial","name":"ANNOUNCE","route":"/trials/announce/"}]}}