{"entity":{"id":"waseem-qasim","kind":"person","name":"Waseem Qasim","aka":[],"tldr":"Delivered the first gene-edited off-the-shelf CAR-T cells to infants with leukaemia and the first base-edited CAR-T therapy.","summary":"Waseem Qasim led the compassionate use and then trials of UCART19, TALEN-edited universal donor CAR T cells, in infants and children with refractory ALL, the first clinical use of gene-edited allogeneic CAR-T. In 2023 his team reported the first patient treated with base-edited CAR7 T cells for T-cell ALL, a disease where autologous CAR-T is impractical. He leads cell and gene therapy at Great Ormond Street.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Qasim%20W%5BAuthor%5D%20CAR%20T%20gene-edited"}],"tags":["cell-therapy","gene-editing","paediatric"],"related":[],"cancers":["all-leukemia"],"sections":[],"technologies":["allogeneic-cell-therapy","car-t","crispr-screens"],"targets":["cd19"],"drugs":[],"companies":[],"institutions":["great-ormond-street"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-ucart19-allogeneic-car-t-lancet-2020"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Cell and Gene Therapy, UCL Great Ormond Street Institute of Child Health","institutionId":"great-ormond-street","specialisms":["Gene-edited cell therapy","Allogeneic CAR T cells","Base editing","Paediatric leukaemia"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Qasim%20W%5BAuthor%5D%20CAR%20T%20gene-edited"}],"papers":[{"title":"Genome-edited allogeneic donor 'universal' anti-CD19 CAR T cells in paediatric and adult B-cell acute lymphoblastic leukaemia (UCART19)","journal":"Lancet","year":2020,"doi":"10.1016/S0140-6736(20)32334-5"},{"title":"Base-edited CAR7 T cells for relapsed T-cell acute lymphoblastic leukemia","journal":"NEJM","year":2023,"doi":"10.1056/NEJMoa2300709"},{"title":"UCART19: the first gene-edited, donor-derived CAR-T cells in children and adults with relapsed B-cell ALL","journal":"The Lancet","year":2020,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=UCART19%20genome-edited%20donor-derived%20allogeneic%20anti-CD19%20CAR%20T%20Benjamin%20Lancet%202020"}],"orcid":"0000-0001-8353-4494"},"route":"/people/waseem-qasim/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"}],"technology":[{"id":"allogeneic-cell-therapy","kind":"technology","name":"Allogeneic (off-the-shelf) cell therapy","route":"/technologies/allogeneic-cell-therapy/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"crispr-screens","kind":"technology","name":"CRISPR functional genomics","route":"/technologies/crispr-screens/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"}],"institution":[{"id":"great-ormond-street","kind":"institution","name":"Great Ormond Street Hospital for Children","route":"/institutions/great-ormond-street/"}],"paper":[{"id":"paper-ucart19-allogeneic-car-t-lancet-2020","kind":"paper","name":"UCART19: the first gene-edited, donor-derived CAR-T cells in children and adults with relapsed B-cell ALL","route":"/key-papers/paper-ucart19-allogeneic-car-t-lancet-2020/"}]}}