{"entity":{"id":"vegfc","kind":"target","name":"VEGFC","aka":["vascular endothelial growth factor C","Vascular endothelial growth factor C","VEGF-C"],"tldr":"VEGFC (Vascular endothelial growth factor C) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sunitinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12682"},{"label":"UniProt P49767","url":"https://www.uniprot.org/uniprotkb/P49767/entry"},{"label":"NCBI Gene 7424","url":"https://www.ncbi.nlm.nih.gov/gene/7424"},{"label":"Ensembl ENSG00000150630","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150630"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VEGFC","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12682","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49767","url":"https://www.uniprot.org/uniprotkb/P49767/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene VEGFC","url":"https://civicdb.org/features/6073","note":"1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA VEGFC: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas VEGFC tissue","url":"https://www.proteinatlas.org/ENSG00000150630-VEGFC/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000150630 associations","url":"https://platform.opentargets.org/target/ENSG00000150630/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:12682","ensembl":"ENSG00000150630","uniprot":"P49767","entrez":"7424","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Joukov et al, EMBO J, 1996, \"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8617204/","biology":"Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Location: Secreted (UniProt). Locus 4q34.3 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/vegfc/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}