{"entity":{"id":"usha-menon","kind":"person","name":"Usha Menon","aka":[],"tldr":"Led UKCTOCS, the 200,000-woman trial that found ovarian cancer screening does not save lives despite detecting cancers earlier.","summary":"Usha Menon was co-principal investigator of UKCTOCS, the largest cancer screening trial ever run, whose 2021 final report showed neither annual CA125-based multimodal screening nor ultrasound reduced ovarian cancer mortality despite a stage shift, a landmark negative result for early detection. She developed the Risk of Ovarian Cancer Algorithm and continues to lead early detection and biobank research at UCL.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Menon%20U%5BAuthor%5D%20UKCTOCS"}],"tags":["screening","ovarian","early-detection"],"related":[],"cancers":["ovarian"],"sections":[],"technologies":["ultrasound"],"targets":[],"drugs":[],"companies":[],"institutions":["uclh"],"pathways":[],"terms":[],"trials":["ukctocs"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Gynaecological Cancer, MRC Clinical Trials Unit at UCL","institutionId":"uclh","specialisms":["Ovarian cancer screening","Population trials","Risk algorithms","Early detection"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Menon%20U%5BAuthor%5D%20UKCTOCS"}],"papers":[{"title":"Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)","journal":"Lancet","year":2021,"doi":"10.1016/S0140-6736(21)00731-5"},{"title":"Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","journal":"Lancet","year":2016,"doi":"10.1016/S0140-6736(15)01224-6"}],"orcid":"0000-0003-3708-1732"},"route":"/people/usha-menon/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"technology":[{"id":"ultrasound","kind":"technology","name":"Ultrasound","route":"/technologies/ultrasound/"}],"institution":[{"id":"uclh","kind":"institution","name":"University College London Hospitals / UCL Cancer Institute","route":"/institutions/uclh/"}],"trial":[{"id":"ukctocs","kind":"trial","name":"UKCTOCS","route":"/trials/ukctocs/"}]}}