{"entity":{"id":"umc-utrecht","kind":"institution","name":"UMC Utrecht Cancer Center","aka":["University Medical Center Utrecht","Utrecht Cancer Center"],"tldr":"The Dutch university cancer centre that invented the MR-linac and sits at the heart of the Utrecht organoid and Oncode ecosystem.","summary":"UMC Utrecht's radiotherapy department under Jan Lagendijk and Bas Raaymakers conceived and built the first integrated MRI-guided linear accelerator, commercialised by Elekta as Unity and used to treat the first patients in Utrecht in 2017. The Cancer Center works with the neighbouring Hubrecht Institute, where Hans Clevers's group grew the first adult stem cell-derived organoids, and with the Princess Máxima Center for paediatric oncology on the same campus; Utrecht is also the seat of the Dutch Oncode Institute. Clinical strengths include image-guided and adaptive radiotherapy, head and neck and gastrointestinal oncology, haematology and a phase 1 unit, and the centre holds OECI accreditation. Patients access MR-guided radiotherapy trials, organoid-guided drug testing studies and molecular tumour boards.","asOf":"2026-09-09","links":[{"label":"Homepage","url":"https://www.umcutrecht.nl/en"},{"label":"Hubrecht Institute","url":"https://www.hubrecht.eu"},{"label":"Oncode Institute","url":"https://www.oncode.nl"}],"tags":[],"related":[],"cancers":["prostate","head-and-neck","colorectal","pancreatic"],"sections":["radiation","diagnostics"],"technologies":["mr-linac","organoids","functional-drug-testing","imrt-igrt","sbrt"],"targets":[],"drugs":[],"companies":["elekta"],"institutions":["princess-maxima","nki","oeci"],"pathways":[],"terms":[],"trials":[],"people":["wouter-de-laat","jurgen-kuball","bas-raaymakers"],"bottlenecks":["b-preclinical-models"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Utrecht","country":"NL","lat":52.087,"lng":5.18,"institutionType":"cancer-center","website":"https://www.umcutrecht.nl/en","university":"Utrecht University","programs":["MR-linac and adaptive radiotherapy","Organoid research (with Hubrecht Institute)","Head and neck oncology","Haematology","Oncode Institute"]},"route":"/institutions/umc-utrecht/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"technology":[{"id":"functional-drug-testing","kind":"technology","name":"Functional (ex vivo) drug testing","route":"/technologies/functional-drug-testing/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"mr-linac","kind":"technology","name":"MR-guided adaptive radiotherapy","route":"/technologies/mr-linac/"},{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"},{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"company":[{"id":"elekta","kind":"company","name":"Elekta","route":"/companies/elekta/"}],"institution":[{"id":"nki","kind":"institution","name":"Netherlands Cancer Institute (NKI-AvL)","route":"/institutions/nki/"},{"id":"oeci","kind":"institution","name":"Organisation of European Cancer Institutes","route":"/institutions/oeci/"},{"id":"princess-maxima","kind":"institution","name":"Princess Máxima Center for Pediatric Oncology","route":"/institutions/princess-maxima/"}],"person":[{"id":"bas-raaymakers","kind":"person","name":"Bas W. Raaymakers","route":"/people/bas-raaymakers/"},{"id":"jurgen-kuball","kind":"person","name":"Jürgen Kuball","route":"/people/jurgen-kuball/"},{"id":"wouter-de-laat","kind":"person","name":"Wouter de Laat","route":"/people/wouter-de-laat/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"}],"paper":[{"id":"paper-sato-lgr5-organoids-nature-2009","kind":"paper","name":"Sato 2009: single Lgr5 stem cells build crypt-villus organoids","route":"/key-papers/paper-sato-lgr5-organoids-nature-2009/"}]}}