{"entity":{"id":"uchicago-cancer","kind":"institution","name":"University of Chicago Medicine Comprehensive Cancer Center","aka":["UCCCC"],"tldr":"Where Charles Huggins proved hormones drive prostate cancer and Janet Rowley found the chromosome translocations behind leukaemia; strong in tumour immunology today.","summary":"NCI-designated since 1973 and comprehensive since 2008, the University of Chicago has two foundational cancer discoveries to its name: Charles Huggins's demonstration that castration controls prostate cancer (Nobel Prize 1966), the origin of hormonal therapy, and Janet Rowley's identification of recurrent chromosomal translocations, including the 9;22 translocation that produces BCR-ABL. Today Thomas Gajewski's laboratory defined the T-cell-inflamed ('hot') tumour phenotype and the gut microbiome's influence on checkpoint response; Everett Vokes established chemoradiotherapy for head and neck cancer; Susan Cohn leads international neuroblastoma risk classification. The centre is building a dedicated cancer hospital on its Hyde Park campus.","asOf":"2026-09-09","links":[{"label":"UChicago Medicine Comprehensive Cancer Center","url":"https://cancer.uchicago.edu"},{"label":"Clinical trials","url":"https://cancer.uchicago.edu/clinical-trials/"}],"tags":[],"related":[],"cancers":["prostate","head-and-neck","neuroblastoma","cml"],"sections":["hormonal","immunotherapy"],"technologies":["androgen-deprivation","microbiome-modulation-io","checkpoint-inhibitor"],"targets":["bcr-abl","androgen-receptor"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["cold-vs-hot"],"trials":[],"people":["everett-vokes","susan-cohn","kunle-odunsi","ralph-weichselbaum","hedy-kindler","thomas-gajewski"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Chicago, IL","country":"US","lat":41.789,"lng":-87.604,"institutionType":"cancer-center","website":"https://cancer.uchicago.edu","nci":"comprehensive","university":"University of Chicago","programs":["Tumour immunology and microbiome","Head and neck cancer","Neuroblastoma (INRG)","Leukaemia genetics"]},"route":"/institutions/uchicago-cancer/","neighbours":{"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"hormonal","kind":"section","name":"Hormonal Therapy","route":"/fronts/hormonal/"},{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"androgen-deprivation","kind":"technology","name":"Androgen deprivation & AR pathway inhibitors","route":"/technologies/androgen-deprivation/"},{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"microbiome-modulation-io","kind":"technology","name":"Microbiome modulation to unlock immunotherapy","route":"/technologies/microbiome-modulation-io/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"},{"id":"bcr-abl","kind":"target","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/targets/bcr-abl/"}],"term":[{"id":"cold-vs-hot","kind":"term","name":"Hot vs cold tumours","route":"/terms/cold-vs-hot/"}],"person":[{"id":"daniel-ludwig","kind":"person","name":"Daniel K. Ludwig","route":"/people/daniel-ludwig/"},{"id":"everett-vokes","kind":"person","name":"Everett E. Vokes","route":"/people/everett-vokes/"},{"id":"hedy-kindler","kind":"person","name":"Hedy L. Kindler","route":"/people/hedy-kindler/"},{"id":"kunle-odunsi","kind":"person","name":"Kunle Odunsi","route":"/people/kunle-odunsi/"},{"id":"ralph-weichselbaum","kind":"person","name":"Ralph Weichselbaum","route":"/people/ralph-weichselbaum/"},{"id":"susan-cohn","kind":"person","name":"Susan L. Cohn","route":"/people/susan-cohn/"},{"id":"thomas-gajewski","kind":"person","name":"Thomas F. Gajewski","route":"/people/thomas-gajewski/"}],"institution":[{"id":"ludwig-cancer-research","kind":"institution","name":"Ludwig Cancer Research","route":"/institutions/ludwig-cancer-research/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"uch-ibadan","kind":"institution","name":"University College Hospital, Ibadan","route":"/institutions/uch-ibadan/"}]}}