{"entity":{"id":"tuba3e","kind":"target","name":"TUBA3E","aka":["tubulin alpha 3e","Tubulin alpha-3E chain"],"tldr":"TUBA3E (Tubulin alpha-3E chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.","summary":"Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.17, genetic association 0.00, clinical 1.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20765","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20765"},{"label":"UniProt Q6PEY2","url":"https://www.uniprot.org/uniprotkb/Q6PEY2/entry"},{"label":"NCBI Gene 112714","url":"https://www.ncbi.nlm.nih.gov/gene/112714"},{"label":"Ensembl ENSG00000152086","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000152086"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","lung-cancer","non-hodgkin-lymphoma","prostate","hodgkin-lymphoma","cervical","multiple-myeloma","sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TUBA3E","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:20765","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20765","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6PEY2","url":"https://www.uniprot.org/uniprotkb/Q6PEY2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000152086","url":"https://platform.opentargets.org/target/ENSG00000152086/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.60, gastric cancer 0.53, prostate cancer 0.59, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0)"}],"distribution":"many-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBA3E: RNA group enriched (heart muscle 51 nTPM, testis 169 nTPM); no normal tissue stained high; highest cancer staining carcinoid (2 of 4 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Cervical cancer, Multiple myeloma, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, non-small cell lung carcinoma, breast carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas TUBA3E tissue","url":"https://www.proteinatlas.org/ENSG00000152086-TUBA3E/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000152086 associations","url":"https://platform.opentargets.org/target/ENSG00000152086/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:20765","ensembl":"ENSG00000152086","uniprot":"Q6PEY2","entrez":"112714","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, \"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/15489334/","biology":"Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 2q21.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)","Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)","Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)","Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)","Cervical cancer: Open Targets association 0.58 with cervical cancer (MONDO_0002974)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tuba3e/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}