{"entity":{"id":"tst003","kind":"drug","name":"TST003","aka":[],"tldr":"TST003 is a monoclonal antibody from Transcenta Therapeutics (Hangzhou) Co., Ltd., in registered phase 2 trials for colorectal cancer.","summary":"TST003 is listed on ClinicalTrials.gov as an intervention in 1 registered phase 2 trial sponsored by Transcenta Therapeutics (Hangzhou) Co., Ltd., in colorectal cancer. A monoclonal antibody, as described in the registry record. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.","status":"phase-2","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of TST003","url":"https://clinicaltrials.gov/search?intr=TST003"},{"label":"ClinicalTrials.gov NCT05731271","url":"https://clinicaltrials.gov/study/NCT05731271"}],"tags":["pipeline","ctgov-ingest","registry-only"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":["grem1"],"drugs":[],"companies":["transcenta"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05731271"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["TST003 is described in its first-in-human registry record as an intravenous humanised anti-GREM1 monoclonal antibody; gremlin-1 is a BMP antagonist that keeps intestinal and tumour cells in a stem-like state."],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2, registry-only)","editedOn":"2026-09-16"},"code":"TST003","modality":"Monoclonal antibody","mechanism":"A monoclonal antibody, as described in the registry record.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/tst003/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"target":[{"id":"grem1","kind":"target","name":"GREM1","route":"/targets/grem1/"}],"company":[{"id":"transcenta","kind":"company","name":"Transcenta","route":"/companies/transcenta/"}],"trial":[{"id":"nct05731271","kind":"trial","name":"A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors","route":"/trials/nct05731271/"}]}}