{"entity":{"id":"tmsb4x","kind":"target","name":"TMSB4X","aka":["thymosin beta 4 X-linked","Thymosin beta-4","TB4X","TMSB4"],"tldr":"TMSB4X (Thymosin beta-4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.","summary":"Plays an important role in the organisation of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerisation. Potent inhibitor of bone marrow derived stem cell differentiation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 6 cohorts (1 activating, 5 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11881","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11881"},{"label":"UniProt P62328","url":"https://www.uniprot.org/uniprotkb/P62328/entry"},{"label":"NCBI Gene 7114","url":"https://www.ncbi.nlm.nih.gov/gene/7114"},{"label":"Ensembl ENSG00000205542","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205542"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TMSB4X","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11881","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11881","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62328","url":"https://www.uniprot.org/uniprotkb/P62328/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TMSB4X","url":"https://civicdb.org/features/5814","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000205542","url":"https://platform.opentargets.org/target/ENSG00000205542/associations","note":"per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.53, non-Hodgkin lymphoma 0.58 (GraphQL API, CC0)"},{"label":"IntOGen TMSB4X","url":"https://www.intogen.org/search?gene=TMSB4X","note":"driver in 6 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"one-type","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA TMSB4X: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (diffuse large B-cell lymphoma). (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P62328","url":"https://www.uniprot.org/uniprotkb/P62328/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TMSB4X","url":"https://civicdb.org/features/5814","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen TMSB4X","url":"https://www.intogen.org/search?gene=TMSB4X","note":"driver in 6 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas TMSB4X tissue","url":"https://www.proteinatlas.org/ENSG00000205542-TMSB4X/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000205542 associations","url":"https://platform.opentargets.org/target/ENSG00000205542/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11881","ensembl":"ENSG00000205542","uniprot":"P62328","entrez":"7114","firstDescribed":1984,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Friedman R.L. et al, Cell, 1984, \"Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/6548414/","biology":"Plays an important role in the organisation of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerisation. Potent inhibitor of bone marrow derived stem cell differentiation. Acts by inhibits the entry of haematopoietic pluripotent stem cells into the S-phase. Location: Cytoplasm, cytoskeleton (UniProt). Locus Xp22.2 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)","Diffuse large B-cell lymphoma: Open Targets association 0.53 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tmsb4x/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}