{"entity":{"id":"tim-somervaille","kind":"person","name":"Tim Somervaille","aka":[],"tldr":"Haematologist and Senior Group Leader at CRUK Manchester Institute studying the transcriptional drivers of acute myeloid leukaemia.","summary":"Tim Somervaille is a Senior Group Leader at the Cancer Research UK Manchester Institute, where his Leukaemia Biology laboratory investigates transcription factors and epigenetic regulators that sustain acute myeloid leukaemia. He is also a consultant haematologist at The Christie NHS Foundation Trust. His group has identified FOXC1 derepression as a recurrent feature in AML and explored EP300/CBP bromodomain inhibition as a therapeutic strategy.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://www.cruk.manchester.ac.uk/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Somervaille+TC%5BAuthor%5D"}],"tags":["clinician-scientist","leukaemia","haematology"],"related":[],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["cruk-manchester-institute"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Senior Group Leader","institutionId":"cruk-manchester-institute","specialisms":["Acute myeloid leukaemia","Leukaemia biology","Haematology"],"profiles":[{"label":"Institution profile","url":"https://www.cruk.manchester.ac.uk/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Somervaille+TC%5BAuthor%5D"}],"papers":[{"title":"Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia","journal":"Cancer Cell","year":2015,"url":"https://doi.org/10.1016/j.ccell.2015.07.017","doi":"10.1016/j.ccell.2015.07.017"},{"title":"Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies","journal":"Cancer Cell","year":2023,"url":"https://doi.org/10.1016/j.ccell.2023.11.001","doi":"10.1016/j.ccell.2023.11.001"}],"orcid":"0000-0002-9188-4379"},"route":"/people/tim-somervaille/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"institution":[{"id":"cruk-manchester-institute","kind":"institution","name":"Cancer Research UK Manchester Institute","route":"/institutions/cruk-manchester-institute/"}]}}