{"entity":{"id":"tec","kind":"target","name":"TEC","aka":["tec protein tyrosine kinase","Tyrosine-protein kinase Tec","PSCTK4"],"tldr":"TEC (Tyrosine-protein kinase Tec) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and an oncogene driver, and an approved or late-stage drug is recorded against it. Tied to Oesophageal cancer and Oesophageal squamous cell carcinoma.","summary":"Non-receptor tyrosine kinase that contributes to signalling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Squamous Cell Carcinoma. In OnCo, 2 product records name it (Ibrutinib and Acalabrutinib).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11719","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11719"},{"label":"UniProt P42680","url":"https://www.uniprot.org/uniprotkb/P42680/entry"},{"label":"NCBI Gene 7006","url":"https://www.ncbi.nlm.nih.gov/gene/7006"},{"label":"Ensembl ENSG00000135605","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135605"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["esophageal","oesophageal-squamous-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["acalabrutinib","ibrutinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 2 OnCo product records name it; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TEC","role":["drug-target","oncogene-driver"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11719","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11719","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42680","url":"https://www.uniprot.org/uniprotkb/P42680/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TEC","url":"https://www.intogen.org/search?gene=TEC","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 2 medicines aimed at it (Acalabrutinib, Ibrutinib) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA TEC: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 21 nTPM); high antibody staining in 10 normal tissues; highest cancer staining lymphoma (9 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Oesophageal cancer); approvals of single-target medicines aimed at it also list Leukaemia, Lymphoma, not counted; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas TEC tissue","url":"https://www.proteinatlas.org/ENSG00000135605-TEC/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000135605 associations","url":"https://platform.opentargets.org/target/ENSG00000135605/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11719","ensembl":"ENSG00000135605","uniprot":"P42680","entrez":"7006","firstDescribed":1994,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Sato et al, Leukemia, 1994, \"Molecular cloning and analysis of the human Tec protein-tyrosine kinase\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7934162/","biology":"Non-receptor tyrosine kinase that contributes to signalling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signalling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Location: Cytoplasm; Cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 4p12-p11 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 1 cohort (ESCC)","Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/tec/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oesophageal-squamous-cell-carcinoma","kind":"cancer","name":"Oesophageal squamous cell carcinoma","route":"/cancers/oesophageal-squamous-cell-carcinoma/"}],"drug":[{"id":"acalabrutinib","kind":"drug","name":"Acalabrutinib","route":"/drugs/acalabrutinib/"},{"id":"ibrutinib","kind":"drug","name":"Ibrutinib","route":"/drugs/ibrutinib/"}]}}