{"entity":{"id":"tc011","kind":"drug","name":"TC011","aka":[],"tldr":"TC011 is an experimental CAR-T cell therapy from TICAROS in phase 2 trials for diffuse large B-cell lymphoma and follicular lymphoma, aimed at CD19.","summary":"TC011 is a CAR-T cell therapy developed by TICAROS. Its target is CD19 (the sponsor names CD19). The sponsor states: TC011 is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, given after fludarabine/cyclophosphamide lymphodepleting chemotherapy, for relapsed/refractory large B-cell non-Hodgkin lymphoma. ClinicalTrials.gov describes the intervention as: Anti-CD19 Chimeric Antigen Receptor T cell. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, in diffuse large B-cell lymphoma and follicular lymphoma. The largest, NCT07473167, plans to enrol 98 participants with primary completion expected 2028-02-11. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.","status":"phase-2","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov: trials of TC011","url":"https://clinicaltrials.gov/search?intr=TC011"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["dlbcl","follicular-lymphoma"],"sections":[],"technologies":[],"targets":["cd19"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct07473167"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"modality":"CAR-T cell therapy","mechanism":"TC011 is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, given after fludarabine/cyclophosphamide lymphodepleting chemotherapy, for relapsed/refractory large B-cell non-Hodgkin lymphoma.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/tc011/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"follicular-lymphoma","kind":"cancer","name":"Follicular lymphoma","route":"/cancers/follicular-lymphoma/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"}],"trial":[{"id":"nct07473167","kind":"trial","name":"Study of Safety and Efficacy of TC011 in the Relapsed/Refractory Large B Cell Non-Hodgkin Lymphoma Patients","route":"/trials/nct07473167/"}]}}