{"entity":{"id":"t030","kind":"term","name":"T030 (belotecan derivative)","aka":["KL610023 payload","belotecan derivative","belotecan derivatives","KL610023"],"tldr":"T030 is the belotecan-derived topoisomerase payload in sacituzumab tirumotecan, designed to be less affected by the pumps that eject SN-38.","summary":"T030 is a camptothecin analogue derived from belotecan. Kelun and MSD report weaker efflux-pump susceptibility than SN-38 and a more stable linker, which may translate into a different resistance and toxicity profile within the same mechanistic class. Evidence comes largely from sponsor data and Chinese trials, so treat cross-class comparisons as provisional.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Belotecan","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Belotecan"}],"tags":[],"related":["topoisomerase-inhibitors","efflux-pump"],"cancers":[],"sections":[],"technologies":["adc"],"targets":[],"drugs":["sacituzumab-tirumotecan"],"companies":[],"institutions":[],"pathways":[],"terms":["payload","topoisomerase-i-payloads"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"ADC chemistry"},"route":"/terms/t030/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"term":[{"id":"efflux-pump","kind":"term","name":"Drug efflux pumps (ABC transporters)","route":"/terms/efflux-pump/"},{"id":"payload","kind":"term","name":"Payload (ADC)","route":"/terms/payload/"},{"id":"topoisomerase-i-payloads","kind":"term","name":"Topoisomerase-I inhibitor payloads","route":"/terms/topoisomerase-i-payloads/"}],"drug":[{"id":"sacituzumab-tirumotecan","kind":"drug","name":"Sacituzumab tirumotecan","route":"/drugs/sacituzumab-tirumotecan/"}]}}