{"entity":{"id":"systimmune","kind":"company","name":"SystImmune / Sichuan Biokin","aka":["Sichuan Baili Pharmaceutical Co., Ltd.","Sichuan Baili Pharmaceutical","Baili-Bio"],"tldr":"SystImmune developed iza-bren, the first bispecific ADC to win a phase 3 trial.","summary":"SystImmune, headquartered in Redmond, Washington, with its parent Sichuan Biokin in Chengdu, developed izalontamab brengitecan, or iza-bren, the first bispecific antibody-drug conjugate to win a phase 3 trial. Iza-bren targets EGFR and HER3 at once and is partnered with Bristol Myers Squibb in a deal worth up to 8.4 billion dollars, and a pipeline of further bispecific ADCs, including trastuzumab brengitecan, follows it. OnCo links it to triple-negative and HER2-positive breast cancer and oesophageal cancer, to the bispecific ADC technology, to Sichuan Cancer Hospital, to Li Zhang, and to the idea of two-target antibody drugs that close the antigen escape route. Acquired resistance to every therapy is the bottleneck the bispecific design is meant to address. Izalontamab brengitecan has its own page.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://www.systimmune.com"}],"tags":[],"related":[],"cancers":[],"sections":["adcs"],"technologies":[],"targets":[],"drugs":["izalontamab-brengitecan","si-b001"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct07625644","nct06838273","nct07502300","nct06382129","nct07518173","nct06830889","nct07640789","nct06994195","nct06316531","nct06118333","nct07642024","nct07178795","nct06500026","nct06891833","nct06382116","nct06475300","nct06498986","nct06668961","nct06437522","nct07054567","nct06114511","nct07654400","nct05880706","nct05956587","nct05990803","nct06006169","nct05949606","nct06445400","nct07264816","nct05924841","nct06008054","nct06437509","nct05020457","nct05044897","nct06787664","nct05054439","nct05192486","nct07678957","nct06131450","nct05944978","nct06042894","nct06343948","nct05668858","nct06598787","nct07518147","nct06857175","nct05623982","nct05803018","nct05627856","nct05965856","nct07582315","nct07606599","nct05949619","nct06957886","nct06405425","nct06031584","nct07554456","nct06471205","nct07255872","nct06978114","nct06962787","nct06066203","nct07648914","nct05785039"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Redmond, WA / Chengdu","country":"US","companyType":"biotech","website":"https://www.systimmune.com","investors":[],"funding":[]},"route":"/companies/systimmune/","neighbours":{"section":[{"id":"adcs","kind":"section","name":"Antibody-Drug Conjugates","route":"/fronts/adcs/"}],"drug":[{"id":"izalontamab-brengitecan","kind":"drug","name":"Izalontamab brengitecan","route":"/drugs/izalontamab-brengitecan/"},{"id":"si-b001","kind":"drug","name":"SI-B001","route":"/drugs/si-b001/"},{"id":"trastuzumab-brengitecan","kind":"drug","name":"Trastuzumab brengitecan","route":"/drugs/trastuzumab-brengitecan/"}],"trial":[{"id":"nct05943795","kind":"trial","name":"A Clinical Study of SI-B001 Combined With Docetaxel in the Treatment of Non-small Cell Lung Adenocarcinoma and Lung Squamous Cell Carcinoma","route":"/trials/nct05943795/"},{"id":"nct05054439","kind":"trial","name":"A Clinical Study of SI-B001 in Combination With Paclitaxel/Docetaxel in the Treatment of Recurrent and Metastatic 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