{"entity":{"id":"susan-clark","kind":"person","name":"Susan Clark","aka":[],"tldr":"Pioneer of DNA methylation analysis whose Garvan laboratory studies how epigenetic changes drive prostate and breast cancer.","summary":"Susan Clark heads the Cancer Epigenetics Laboratory at the Garvan Institute of Medical Research in Sydney. She developed the bisulphite sequencing method that made genome-wide DNA methylation mapping possible, and her group investigates epigenome remodelling in prostate and breast cancer and its use in biomarkers. She is a Fellow of the Australian Academy of Science.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Clark+SJ%5BAuthor%5D+methylation"}],"tags":["clinician-scientist","epigenetics","prostate cancer","breast cancer"],"related":[],"cancers":["prostate","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["garvan-institute"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Head of the Cancer Epigenetics Laboratory","institutionId":"garvan-institute","specialisms":["Cancer epigenetics","DNA methylation","Prostate and breast cancer"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Clark+SJ%5BAuthor%5D+methylation"}],"papers":[{"title":"DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer","journal":"Nature Communications","year":2015,"doi":"10.1038/ncomms8758"},{"title":"Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value","journal":"Nature Communications","year":2015,"doi":"10.1038/ncomms6899"},{"title":"Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer","journal":"Nature Communications","year":2020,"doi":"10.1038/s41467-019-14098-x"}],"orcid":"0000-0001-5925-5030"},"route":"/people/susan-clark/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"institution":[{"id":"garvan-institute","kind":"institution","name":"Garvan Institute of Medical Research / Kinghorn Cancer Centre","route":"/institutions/garvan-institute/"}]}}