{"entity":{"id":"sunnybrook-odette","kind":"institution","name":"Sunnybrook Odette Cancer Centre","aka":["Odette Cancer Centre","Sunnybrook Health Sciences Centre"],"tldr":"One of Canada's largest cancer centres, where focused ultrasound first opened the blood-brain barrier in a patient and Canada's first MR-linac was installed.","summary":"The Odette Cancer Centre at Sunnybrook Health Sciences Centre is one of Canada's largest cancer programmes and a University of Toronto teaching site. Sunnybrook Research Institute's Kullervo Hynynen pioneered MR-guided focused ultrasound, and in 2015 neurosurgeon Todd Mainprize used it to open the blood-brain barrier non-invasively in a brain tumour patient for the first time, work now in trials for glioblastoma and brain metastases with Insightec. Radiation oncology is a signature strength: Arjun Sahgal led the CCTG SC.24 trial of stereotactic radiotherapy for spinal metastases, Gregory Czarnota develops ultrasound-stimulated microbubble radiosensitisation, and Sunnybrook installed Canada's first MR-linac. The Odette Breast Centre and a large GU programme (including prostate brachytherapy) complete the picture.","asOf":"2026-09-09","links":[{"label":"Odette Cancer Centre","url":"https://sunnybrook.ca/content/?page=odette-cancer-centre"},{"label":"Sunnybrook Research Institute","url":"https://sunnybrook.ca/research/"}],"tags":[],"related":[],"cancers":["glioblastoma","prostate","breast-hr-positive"],"sections":[],"technologies":["bbb-focused-ultrasound","hifu-histotripsy","mr-linac","sbrt","brachytherapy","gamma-knife","radiosurgery-srs"],"targets":[],"drugs":[],"companies":["insightec","elekta","cctg"],"institutions":["princess-margaret"],"pathways":[],"terms":["oligometastatic"],"trials":[],"people":["monika-krzyzanowska","simron-singh"],"bottlenecks":["b-brain-delivery"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Toronto, ON","country":"CA","lat":43.723,"lng":-79.375,"institutionType":"cancer-center","website":"https://sunnybrook.ca/content/?page=odette-cancer-centre","university":"University of Toronto","programs":["Focused ultrasound and blood-brain barrier opening","MR-linac and stereotactic radiotherapy","Breast cancer","Genitourinary oncology"]},"route":"/institutions/sunnybrook-odette/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"brachytherapy","kind":"technology","name":"Brachytherapy","route":"/technologies/brachytherapy/"},{"id":"hifu-histotripsy","kind":"technology","name":"Focused ultrasound & histotripsy","route":"/technologies/hifu-histotripsy/"},{"id":"bbb-focused-ultrasound","kind":"technology","name":"Focused-ultrasound blood-brain barrier opening","route":"/technologies/bbb-focused-ultrasound/"},{"id":"gamma-knife","kind":"technology","name":"Gamma Knife","route":"/technologies/gamma-knife/"},{"id":"mr-linac","kind":"technology","name":"MR-guided adaptive radiotherapy","route":"/technologies/mr-linac/"},{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"},{"id":"radiosurgery-srs","kind":"technology","name":"Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)","route":"/technologies/radiosurgery-srs/"},{"id":"transcranial-focused-ultrasound-systems","kind":"technology","name":"Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud)","route":"/technologies/transcranial-focused-ultrasound-systems/"}],"company":[{"id":"cctg","kind":"company","name":"Canadian Cancer Trials Group (CCTG)","route":"/companies/cctg/"},{"id":"elekta","kind":"company","name":"Elekta","route":"/companies/elekta/"},{"id":"insightec","kind":"company","name":"Insightec","route":"/companies/insightec/"}],"institution":[{"id":"ontario-health-cancer-care-ontario","kind":"institution","name":"Ontario Health (Cancer Care Ontario)","route":"/institutions/ontario-health-cancer-care-ontario/"},{"id":"princess-margaret","kind":"institution","name":"Princess Margaret Cancer Centre","route":"/institutions/princess-margaret/"}],"term":[{"id":"oligometastatic","kind":"term","name":"Oligometastatic disease","route":"/terms/oligometastatic/"}],"person":[{"id":"monika-krzyzanowska","kind":"person","name":"Monika Krzyzanowska","route":"/people/monika-krzyzanowska/"},{"id":"simron-singh","kind":"person","name":"Simron Singh","route":"/people/simron-singh/"}],"bottleneck":[{"id":"b-brain-delivery","kind":"bottleneck","name":"The brain: barrier and sanctuary","route":"/bottlenecks/b-brain-delivery/"}],"roadmap":[{"id":"devices-roadmap","kind":"roadmap","name":"Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants","route":"/roadmaps/devices-roadmap/"}]}}