{"entity":{"id":"stefan-pfister","kind":"person","name":"Stefan Pfister","aka":[],"tldr":"Paediatric oncologist whose genomic work redefined childhood brain tumours into molecular subgroups.","summary":"Stefan Pfister is Director of the Hopp Children's Cancer Center Heidelberg (KiTZ) and Head of Pediatric Neurooncology at the German Cancer Research Center (DKFZ), working with Heidelberg University Hospital and the NCT. His specialisms are paediatric neuro-oncology, brain tumour genomics and molecular classification. He led the molecular subgrouping of medulloblastoma and ependymoma, work that redefined childhood brain tumours into molecular subgroups. He also co-developed the DNA methylation-based classifier for central nervous system tumours, reported in Nature. His publications are listed on PubMed.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Stefan_Pfister","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pfister%20SM%5BAuthor%5D%20medulloblastoma"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["methylation-profiling"],"targets":[],"drugs":[],"companies":[],"institutions":["dkfz","heidelberg-nct"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Hopp Children's Cancer Center Heidelberg (KiTZ); Head of Pediatric Neurooncology, DKFZ","institutionId":"dkfz","specialisms":["Paediatric neuro-oncology","Brain tumour genomics","Molecular classification"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pfister%20SM%5BAuthor%5D%20medulloblastoma"}],"papers":[{"title":"DNA methylation-based classification of central nervous system tumours","journal":"Nature","year":2018,"doi":"10.1038/nature26000"}],"orcid":"0000-0002-5447-5322"},"route":"/people/stefan-pfister/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"methylation-profiling","kind":"technology","name":"DNA methylation profiling","route":"/technologies/methylation-profiling/"}],"institution":[{"id":"dkfz","kind":"institution","name":"German Cancer Research Center (DKFZ)","route":"/institutions/dkfz/"},{"id":"heidelberg-nct","kind":"institution","name":"Heidelberg University Hospital / NCT / DKFZ","route":"/institutions/heidelberg-nct/"}],"idea":[{"id":"idea-bio2-paediatric-first-development","kind":"idea","name":"Develop drugs in children first when the target is a children's target","route":"/ideas/idea-bio2-paediatric-first-development/"}]}}