{"entity":{"id":"stag3","kind":"target","name":"STAG3","aka":["STAG3 cohesin complex component","Cohesin subunit SA-3","SA3"],"tldr":"STAG3 (Cohesin subunit SA-3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vemurafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11356"},{"label":"UniProt Q9UJ98","url":"https://www.uniprot.org/uniprotkb/Q9UJ98/entry"},{"label":"NCBI Gene 10734","url":"https://www.ncbi.nlm.nih.gov/gene/10734"},{"label":"Ensembl ENSG00000066923","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000066923"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"STAG3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11356","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UJ98","url":"https://www.uniprot.org/uniprotkb/Q9UJ98/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene STAG3","url":"https://civicdb.org/features/8552","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA STAG3: RNA tissue enriched (testis 50 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas STAG3 tissue","url":"https://www.proteinatlas.org/ENSG00000066923-STAG3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000066923 associations","url":"https://platform.opentargets.org/target/ENSG00000066923/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11356","ensembl":"ENSG00000066923","uniprot":"Q9UJ98","entrez":"10734","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Pezzi et al, FASEB J, 2000, \"STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10698974/","biology":"Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Location: Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 7q22.1 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/stag3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}