{"entity":{"id":"srms","kind":"target","name":"SRMS","aka":["src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites","Tyrosine-protein kinase Srms","dJ697K14.1","PTK70","C20orf148"],"tldr":"SRMS (Tyrosine-protein kinase Srms) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Non-Hodgkin lymphoma and 2 more.","summary":"Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.40, genetic association 0.00, clinical 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11298","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11298"},{"label":"UniProt Q9H3Y6","url":"https://www.uniprot.org/uniprotkb/Q9H3Y6/entry"},{"label":"NCBI Gene 6725","url":"https://www.ncbi.nlm.nih.gov/gene/6725"},{"label":"Ensembl ENSG00000125508","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125508"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","non-hodgkin-lymphoma","cml","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SRMS","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11298","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11298","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H3Y6","url":"https://www.uniprot.org/uniprotkb/Q9H3Y6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000125508","url":"https://platform.opentargets.org/target/ENSG00000125508/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.54, non-Hodgkin lymphoma 0.55, chronic myelogenous leukaemia, BCR-ABL1 positive 0.58, myeloproliferative neoplasm 0.58, leukaemia 0.59 (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SRMS: RNA tissue enhanced (epididymis 2 nTPM, lymphoid tissue 2 nTPM, stomach 1 2 nTPM); no normal tissue stained high; highest cancer staining head and neck cancer (2 of 3 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Myeloid neoplasms, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (chronic myeloid leukemia, acute lymphoblastic leukemia). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas SRMS tissue","url":"https://www.proteinatlas.org/ENSG00000125508-SRMS/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000125508 associations","url":"https://platform.opentargets.org/target/ENSG00000125508/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11298","ensembl":"ENSG00000125508","uniprot":"Q9H3Y6","entrez":"6725","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Deloukas et al, Nature, 2001, \"The DNA sequence and comparative analysis of human chromosome 20\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11780052/","biology":"Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR. Location: Cytoplasm (UniProt). Locus 20q13.33 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076)","Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)","Chronic myeloid leukaemia: Open Targets association 0.58 with chronic myelogenous leukaemia, BCR-ABL1 positive (MONDO_0011996)","Acute lymphoblastic leukaemia: Open Targets association 0.54 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/srms/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}