{"entity":{"id":"sotevtamab","kind":"drug","name":"Sotevtamab","aka":["AB-16B5"],"tldr":"Sotevtamab is a monoclonal antibody from Alethia Biotherapeutics, in registered phase 2 trials for colorectal cancer.","summary":"Sotevtamab is listed on ClinicalTrials.gov as an intervention in 1 registered phase 2 trial sponsored by Alethia Biotherapeutics, in colorectal cancer. A monoclonal antibody: the international non-proprietary name stem -mab marks an antibody that binds one target. The registry record does not state the target unless named in the trial entries below. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.","status":"phase-2","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of Sotevtamab","url":"https://clinicaltrials.gov/search?intr=Sotevtamab"},{"label":"ClinicalTrials.gov NCT06225843","url":"https://clinicaltrials.gov/study/NCT06225843"}],"tags":["pipeline","ctgov-ingest","registry-only"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["alethia-biotherapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06225843"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Sotevtamab (AB-16B5) is described in its registry record as a fully humanised IgG2 monoclonal antibody against tumour-associated secreted clusterin, given as an inhibitor of the epithelial-to-mesenchymal transition; it is being tested with FOLFOX before resection of colorectal liver metastases. Clusterin has no target record in the corpus yet."],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2, registry-only)","editedOn":"2026-09-16"},"modality":"Monoclonal antibody","mechanism":"A monoclonal antibody: the international non-proprietary name stem -mab marks an antibody that binds one target. The registry record does not state the target unless named in the trial entries below.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/sotevtamab/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"company":[{"id":"alethia-biotherapeutics","kind":"company","name":"Alethia Biotherapeutics","route":"/companies/alethia-biotherapeutics/"}],"trial":[{"id":"nct06225843","kind":"trial","name":"Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis","route":"/trials/nct06225843/"}]}}